SERPINA12

Across TCGA cell cohorts, SERPINA12 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SERPINA12-associated genes across cancer lineages are OR8B4, USP17L3, and DYTN. Each is linked with SERPINA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA12-to-partner and partner-to-SERPINA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B4 grouped by SERPINA12-low versus SERPINA12-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA12→partner) and Y-score (partner→SERPINA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8B4 →	+0.039	+4.472	<.001	.001	3	2
LUNG_NSCLC_LUSC	USP17L3 →	+0.024	+4.584	.001	.001	3	1
LUNG_NSCLC_LUSC	DYTN →	+0.007	+4.108	<.001	.005	3	1
SKIN	RBMY1F →	+0.086	+6.022	<.001	.001	3	1
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
LARGE_INTESTINE	BMP10 →	+0.020	+4.467	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR8B4 by SERPINA12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →