Across TCGA patient cohorts, SERPINA11 mutation is significantly associated with the RNA expression of many other genes, with 1,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA11-associated genes across cancer lineages are GPR108, COX15, and AP1S3. Each is linked with SERPINA11 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA11-to-partner and partner-to-SERPINA11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA11→partner) and Y-score (partner→SERPINA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GPR108 →	+0.327	+3.001	.002	<.001	3	3
UCEC	COX15 →	+0.470	+3.375	.001	.004	3	2
UCEC	AP1S3 →	+0.767	+3.053	<.001	<.001	3	2
UCEC	BUB3 →	+0.610	+3.775	<.001	<.001	3	2
UCEC	NTAN1 →	+0.532	+3.483	<.001	.002	3	2
UCEC	VPS26C →	+0.451	+3.000	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,858 associations by consensus.

Exploration

SERPINA11 survival (RNA) · tumor vs normal (RNA) · all SERPINA11 data types