Across TCGA patient cohorts, SERPINA11 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA11-associated genes across cancer lineages are PCNA, TFRC, and C-Raf. Each is linked with SERPINA11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA11-to-partner and partner-to-SERPINA11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA11→partner) and Y-score (partner→SERPINA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.316	+3.459	.003	.005	3	2
UCEC	TFRC →	+0.549	+2.321	.039	.035	3	2
UCEC	C-Raf →	+0.250	+3.459	<.001	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.247	-2.308	.003	.036	3	1
UCEC	MEK1_p_S217_S221 →	-0.281	-3.000	.040	.036	3	1
UCEC	Notch1 →	+0.208	+2.817	.003	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

SERPINA11 survival (RNA) · tumor vs normal (RNA) · all SERPINA11 data types