SERPINA10

Across TCGA pan-cancer cohorts, SERPINA10 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SERPINA10 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SERPINA10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINA10 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BLCA, SKCM, and OV are the cancer types where SERPINA10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.160	0.610	<.001	33	view →
SKCM	DFS	Median	II,III,IV	0.891	0.657	.003	22	view →
OV	DFS	Median	All	0.104	0.541	<.001	18	view →
ACC	OS	Median	All	0.287	0.809	<.001	18	view →
BRCA	OS	Median	III,IV	0.313	0.834	.004	14	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
HNSC	DFS	Median	II,III,IV	0.263	0.665	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SERPINA10–BLCA (OS)

Open the BLCA breakdown →