SERPINA10

Across TCGA pan-cancer cohorts, SERPINA10 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SERPINA10 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SERPINA10 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINA10 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where SERPINA10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.206	0.918	<.001	35	view →
CCRCC	DFS	Median	All	0.879	0.630	.004	18	view →
PDAC	OS	Tertile	II,III,IV	0.641	0.996	.002	14	view →
LSCC	OS	Median	All	0.922	1.000	.012	9	view →
GBM	OS	Median	All	0.269	0.502	.008	8	view →
HNSC	DFS	Tertile	III,IV	0.298	0.825	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SERPINA10–LUAD (OS)

Open the LUAD breakdown →