SERPINA10

Across TCGA patient cohorts, SERPINA10 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA10-associated genes across cancer lineages are p53, eEF2, and TFRC. Each is linked with SERPINA10 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA10-to-partner and partner-to-SERPINA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by SERPINA10-low versus SERPINA10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA10→partner) and Y-score (partner→SERPINA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p53 →	+0.120	+1.906	.026	.013	3	2
UCEC	eEF2 →	+0.562	+2.459	.001	.020	2	3
UCEC	TFRC →	+0.594	+2.459	.020	.020	3	2
UCEC	Caspase-7-cleavedD198 →	+0.705	+3.189	.013	.010	3	2
UCEC	Caspase-8 →	-0.251	-2.973	.038	.035	3	2
SKCM	EGFR_pY1068 →	+0.094	+2.087	.042	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

p53 by SERPINA10 expression — SKCM

Explore this box plot interactively →