Across TCGA pan-cancer cohorts, SERPINA1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SERPINA1 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SERPINA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and ACC are the cancer types where SERPINA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.147	0.579	.003	16	view →
UCEC	DFS	Median	All	1.000	0.632	.013	12	view →
ACC	OS	Median	All	0.268	0.802	.010	12	view →
LGG	OS	Median	All	0.300	0.830	.004	6	view →
LUAD	DFS	Median	II,III,IV	0.098	0.651	.001	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SERPINA1 tumor-vs-normal RNA expression · all SERPINA1 data types