Across TCGA patient cohorts, SERPINA1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA1-associated genes across cancer lineages are 4E-BP1, ACC_pS79, and FOXO3a. Each is linked with SERPINA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA1-to-partner and partner-to-SERPINA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA1→partner) and Y-score (partner→SERPINA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.304	+2.999	.006	.035	3	2
UCEC	ACC_pS79 →	+0.288	+1.807	.044	.027	3	1
UCEC	FOXO3a →	-0.147	-3.429	<.001	.005	2	2
UCEC	ACC1 →	+0.362	+2.321	.015	.006	3	1
UCEC	Heregulin →	-0.101	-2.000	.046	.030	3	1
UCEC	Ku80 →	+0.239	+2.179	.014	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

SERPINA1 survival (RNA) · tumor vs normal (RNA) · all SERPINA1 data types