SERPINA1

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, SERPINA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,075 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SERPINA1-associated GO terms across cancer lineages are SRP-dependent cotranslational protein targeting to membrane, translocation, Urokinase plasminogen activator signaling pathway, and Regulation of protein processing. Each is linked with SERPINA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SERPINA1-to-partner and partner-to-SERPINA1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA1→partner) and Y-score (partner→SERPINA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OESOPHAGUSSRP-dependent cotranslational protein targeting to membrane, translocation →+0.130+2.130.001.004310
LUNG_NSCLC_LUSCUrokinase plasminogen activator signaling pathway →+1.064+3.593.004.00139
CNSRegulation of protein processing →+0.112+1.339.004.009210
OVARYRegulation of phagocytosis →+0.095+2.781.002.00139
LUNG_NSCLC_LUSCPositive regulation of phagocytosis →+0.141+2.576<.001.00639
STOMACHEstablishment of protein localization to membrane →+0.064+2.321.002.00538
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,075 associations by consensus.

Exploration