Across TCGA cell cohorts, SERPINA1 mutation is significantly associated with the RNA expression of many other genes, with 516 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERPINA1-associated genes across cancer lineages are IL3, PRAMEF10, and PRAMEF17. Each is linked with SERPINA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA1-to-partner and partner-to-SERPINA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA1→partner) and Y-score (partner→SERPINA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	1
LARGE_INTESTINE	CCDC134 →	+0.765	+3.364	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 516 associations by consensus.

Exploration

SERPINA1 survival (RNA) · tumor vs normal (RNA) · all SERPINA1 data types