SERP1

Across TCGA cell cohorts, SERP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,527 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SERP1-associated GO terms across cancer lineages are Protein targeting to ER, Establishment of protein localization to endoplasmic reticulum, and Post-translational protein targeting to membrane, translocation. Each is linked with SERP1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SERP1-to-partner and partner-to-SERP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to ER grouped by SERP1-low versus SERP1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERP1→partner) and Y-score (partner→SERP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein targeting to ER →	+0.086	+0.633	.001	<.001	3	10
SOFT_TISSUE	Establishment of protein localization to endoplasmic reticulum →	+0.102	+0.737	<.001	<.001	3	9
SOFT_TISSUE	Post-translational protein targeting to membrane, translocation →	+0.080	+0.702	.007	.001	2	10
BREAST	Regulation of Golgi organization →	+0.068	+0.662	.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.107	+1.038	.003	<.001	3	9
LARGE_INTESTINE	Peptidyl-methionine modification →	+0.154	+0.600	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,527 associations by consensus.

Protein targeting to ER by SERP1 expression — LIVER

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