SERINC5

Across TCGA pan-cancer cohorts, SERINC5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SERINC5 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SERINC5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERINC5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, UCEC, and LSCC are the cancer types where SERINC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.932	1.000	.035	18	view →
UCEC	OS	Quartile	All	1.000	0.874	.032	4	view →
LSCC	OS	Tertile	III,IV	0.989	0.491	.028	4	view →
LUAD	OS	Tertile	II,III,IV	0.809	0.319	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SERINC5–COAD (DFS)

Open the COAD breakdown →