SERINC5

Across TCGA patient cohorts, SERINC5 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC5-associated genes across cancer lineages are Ku80, MIG-6, and GATA3. Each is linked with SERINC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC5-to-partner and partner-to-SERINC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SERINC5-low versus SERINC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC5→partner) and Y-score (partner→SERINC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.358	+2.820	.013	.036	3	1
UCEC	MIG-6 →	+0.157	+2.820	.009	.036	3	1
UCEC	GATA3 →	+0.269	+2.820	.020	.036	1	1
UCEC	YB-1 →	+0.267	+2.833	.006	.035	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Ku80 by SERINC5 expression — UCEC

Explore this box plot interactively →