SERINC5

Across TCGA cell cohorts, SERINC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,213 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SERINC5-associated GO terms across cancer lineages are Glycerophospholipid biosynthetic process, Lipid translocation, and Glycerolipid biosynthetic process. Each is linked with SERINC5 in more than 10 cancer types. Because this analysis shows association rather than direction, both SERINC5-to-partner and partner-to-SERINC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycerophospholipid biosynthetic process grouped by SERINC5-low versus SERINC5-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC5→partner) and Y-score (partner→SERINC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Glycerophospholipid biosynthetic process →	+0.061	+2.413	<.001	<.001	3	11
KIDNEY	Lipid translocation →	+0.076	+1.261	<.001	<.001	3	11
URINARY_TRACT	Glycerolipid biosynthetic process →	+0.057	+2.122	<.001	<.001	3	10
URINARY_TRACT	Glycerophospholipid metabolic process →	+0.049	+1.992	<.001	<.001	3	10
OVARY	Phospholipid biosynthetic process →	+0.043	+1.374	<.001	.001	3	10
URINARY_TRACT	Phospholipid transport →	+0.078	+2.156	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,213 associations by consensus.

Glycerophospholipid biosynthetic process by SERINC5 expression — URINARY_TRACT

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