Across TCGA patient cohorts, SERINC4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC4-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and eIF4G. Each is linked with SERINC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC4-to-partner and partner-to-SERINC4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC4→partner) and Y-score (partner→SERINC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.254	-2.115	.020	.019	3	1
UCEC	eIF4E →	+0.257	+2.807	.005	.003	3	1
UCEC	eIF4G →	+0.300	+2.999	.027	.035	3	1
UCEC	FoxM1 →	+0.280	+2.115	.013	.019	3	1
UCEC	JNK2 →	+0.288	+3.196	<.001	.009	3	1
UCEC	Ku80 →	+0.265	+2.128	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

SERINC4 survival (RNA) · tumor vs normal (RNA) · all SERINC4 data types