Across TCGA cell cohorts, SERINC4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERINC4-associated genes across cancer lineages are CACNG3, SPHKAP, and GYPB. Each is linked with SERINC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC4-to-partner and partner-to-SERINC4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC4→partner) and Y-score (partner→SERINC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CACNG3 →	+0.030	+4.906	<.001	.006	3	1
LARGE_INTESTINE	SPHKAP →	+0.013	+5.415	<.001	.004	3	1
LARGE_INTESTINE	GYPB →	+0.132	+4.977	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	TOPAZ1 →	+0.166	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	PTH →	+0.031	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

SERINC4 survival (RNA) · tumor vs normal (RNA) · all SERINC4 data types