SERINC3

Across TCGA pan-cancer cohorts, SERINC3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SERINC3 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SERINC3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SERINC3 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where SERINC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.599	1.000	<.001	63	view →
LSCC	DFS	Quartile	II,III,IV	0.447	0.815	.013	8	view →
LUAD	DFS	Quartile	II,III,IV	0.447	0.925	.022	7	view →
HNSC	OS	Median	All	1.000	0.960	.027	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SERINC3–CCRCC (OS)

Open the CCRCC breakdown →