SERINC3

Across TCGA patient cohorts, SERINC3 mutation is significantly associated with the RNA expression of many other genes, with 976 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC3-associated genes across cancer lineages are RRP9, LINC01707, and RN7SL542P. Each is linked with SERINC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERINC3-to-partner and partner-to-SERINC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RRP9 grouped by SERINC3-low versus SERINC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC3→partner) and Y-score (partner→SERINC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRP9 →	+0.429	+3.374	.003	.004	3	3
BLCA	LINC01707 →	+0.103	+2.564	.001	.007	3	2
BLCA	RN7SL542P →	+0.071	+3.566	<.001	.003	3	2
SKCM	MRPL57 →	+0.409	+3.214	.009	.009	3	2
SKCM	OR7E97P →	+0.015	+4.485	<.001	.004	3	2
SKCM	C7orf66 →	+0.067	+3.394	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 976 associations by consensus.

RRP9 by SERINC3 expression — UCEC

Explore this box plot interactively →