SERINC3

Across TCGA patient cohorts, SERINC3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC3-associated genes across cancer lineages are MEK1, 4E-BP1, and EGFR_pY1068. Each is linked with SERINC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC3-to-partner and partner-to-SERINC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SERINC3-low versus SERINC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC3→partner) and Y-score (partner→SERINC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.502	+2.584	.003	.010	3	2
UCEC	4E-BP1 →	+0.417	+2.351	<.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.281	-2.999	.016	.035	3	1
UCEC	FoxM1 →	+0.337	+2.584	.005	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.151	-3.312	.009	.010	3	1
UCEC	FOXO3a →	+0.099	+1.887	.035	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by SERINC3 expression — UCEC

Explore this box plot interactively →