SERINC3

Across TCGA cell cohorts, SERINC3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,273 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SERINC3-associated genes across cancer lineages are ENG, GDNF, and GPR1. Each is linked with SERINC3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SERINC3-to-partner and partner-to-SERINC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SERINC3 versus ENG in LUNG_NSCLC_LUAD, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC3→partner) and Y-score (partner→SERINC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ENG →	+2.215	+1.194	.006	.002	2	6
KIDNEY	GDNF →	+2.706	+1.244	.001	.008	3	3
LUNG_NSCLC_LUAD	GPR1 →	+2.653	+1.075	.001	.001	3	3
KIDNEY	PLPP4 →	+4.158	+1.244	.003	.008	3	3
OVARY	SPATA6L →	-1.547	-2.220	.001	<.001	3	3
BREAST	CDHR3 →	+1.290	+1.285	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,273 associations by consensus.

SERINC3 vs ENG — LUNG_NSCLC_LUAD

Explore this scatter interactively →