SERINC3

Across TCGA cell cohorts, SERINC3 protein abundance is significantly associated with the go_rna of many other GO terms, with 788 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SERINC3-associated GO terms across cancer lineages are Type 2 mitophagy, Neurotransmitter secretion, and Signal release from synapse. Each is linked with SERINC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SERINC3-to-partner and partner-to-SERINC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Type 2 mitophagy grouped by SERINC3-low versus SERINC3-high in BREAST.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC3→partner) and Y-score (partner→SERINC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Type 2 mitophagy →	+0.248	+1.302	.001	.003	3	4
SKIN	Neurotransmitter secretion →	-0.086	-1.034	.002	.004	3	3
SKIN	Signal release from synapse →	-0.086	-1.034	.002	.004	3	3
LUNG_NSCLC_LUAD	Tricuspid valve morphogenesis →	+0.167	+1.025	.002	.003	3	3
LUNG_NSCLC_LUAD	Negative regulation of protein homooligomerization →	+0.180	+1.056	<.001	.002	3	3
LUNG_NSCLC_LUAD	Negative regulation of multicellular organism growth →	-0.180	-1.221	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 788 associations by consensus.

Type 2 mitophagy by SERINC3 expression — BREAST

Explore this box plot interactively →