SERINC2

Across TCGA patient cohorts, SERINC2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC2-associated genes across cancer lineages are eIF4E, INPP4B, and MEK1. Each is linked with SERINC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC2-to-partner and partner-to-SERINC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SERINC2-low versus SERINC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC2→partner) and Y-score (partner→SERINC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.250	+3.459	.018	.005	3	1
UCEC	INPP4B →	-0.364	-3.169	.025	.018	3	1
UCEC	MEK1 →	+0.375	+2.321	.041	.035	3	1
UCEC	Claudin-7 →	-0.699	-3.459	.005	.005	3	1
UCEC	Di-Ras3 →	-0.152	-2.321	.041	.035	3	1
UCEC	p62 Lck ligand →	+0.550	+3.459	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

eIF4E by SERINC2 expression — UCEC

Explore this box plot interactively →