SERINC1

Across TCGA pan-cancer cohorts, SERINC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SERINC1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SERINC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERINC1 expression acts as an unfavorable survival marker.

HNSC, LUAD, and PDAC are the cancer types where SERINC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.328	0.889	.014	18	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	12	view →
PDAC	DFS	Median	All	0.337	0.540	.012	6	view →
CCRCC	OS	Tertile	All	0.776	0.947	.015	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SERINC1–HNSC (DFS)

Open the HNSC breakdown →