SERINC1

Across TCGA patient cohorts, SERINC1 mutation is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC1-associated genes across cancer lineages are OR10G6, RN7SKP279, and RNF19BPY. Each is linked with SERINC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERINC1-to-partner and partner-to-SERINC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G6 grouped by SERINC1-low versus SERINC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC1→partner) and Y-score (partner→SERINC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR10G6 →	+0.434	+5.893	<.001	.002	3	3
PRAD	RN7SKP279 →	+0.119	+7.939	<.001	.008	3	3
UCEC	RNF19BPY →	+0.021	+4.253	<.001	.004	3	3
SKCM	RNU6-629P →	+0.283	+5.469	<.001	.002	3	2
SKCM	GOT2P1 →	+0.025	+4.867	<.001	.005	3	2
COAD	SEZ6L-AS1 →	+0.204	+6.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

OR10G6 by SERINC1 expression — COAD

Explore this box plot interactively →