SERINC1

Across TCGA patient cohorts, SERINC1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC1-associated genes across cancer lineages are INPP4B, MEK1, and PCNA. Each is linked with SERINC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC1-to-partner and partner-to-SERINC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SERINC1-low versus SERINC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC1→partner) and Y-score (partner→SERINC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.326	-3.169	.030	.018	3	1
UCEC	MEK1 →	+0.416	+3.321	.014	.010	3	1
UCEC	PCNA →	+0.236	+3.169	.018	.018	3	1
UCEC	VHL →	-0.995	-2.459	.001	.019	3	1
UCEC	ATM →	-0.493	-3.000	.019	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.978	+3.341	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

INPP4B by SERINC1 expression — UCEC

Explore this box plot interactively →