SERHL2

Across TCGA patient cohorts, SERHL2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERHL2-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with SERHL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERHL2-to-partner and partner-to-SERHL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SERHL2-low versus SERHL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERHL2→partner) and Y-score (partner→SERHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.327	+2.999	.027	.035	3	1
UCEC	EGFR_pY1068 →	-0.307	-2.321	.002	.006	3	1
UCEC	A-Raf_pS299 →	-0.144	-1.807	.003	.027	3	1
UCEC	JNK2 →	+0.236	+2.469	.004	.010	3	1
UCEC	p62 Lck ligand →	+0.417	+2.594	.001	.006	3	1
UCEC	PCNA →	+0.225	+2.584	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eEF2 by SERHL2 expression — UCEC

Explore this box plot interactively →