SERHL

Across TCGA patient cohorts, SERHL mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SERHL-associated genes across cancer lineages are H2AB3, BTG3P1, and RNA5SP461. Each is linked with SERHL in more than 1 cancer types. Because this analysis shows association rather than direction, both SERHL-to-partner and partner-to-SERHL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AB3 grouped by SERHL-low versus SERHL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERHL→partner) and Y-score (partner→SERHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	H2AB3 →	+0.109	+7.816	<.001	.008	3	1
SKCM	BTG3P1 →	+0.089	+7.816	<.001	.008	3	1
SKCM	RNA5SP461 →	+0.468	+7.816	<.001	.008	3	1
BRCA	RNU6-1312P →	+0.239	+9.057	<.001	.003	3	1
BRCA	RNU6-326P →	+0.237	+7.731	<.001	.009	3	1
BRCA	ZNF736P11Y →	+0.024	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

H2AB3 by SERHL expression — SKCM

Explore this box plot interactively →