SERGEF

Across TCGA patient cohorts, SERGEF protein abundance is significantly associated with the RNA expression of many other genes, with 3,403 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SERGEF-associated genes across cancer lineages are USP47, TRIM68, and LRRC66. Each is linked with SERGEF in more than 3 cancer types. Because this analysis shows association rather than direction, both SERGEF-to-partner and partner-to-SERGEF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SERGEF versus USP47 in LSCC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERGEF→partner) and Y-score (partner→SERGEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP47 →	+0.374	+0.266	<.001	<.001	3	4
LUAD	TRIM68 →	+0.611	+0.179	.003	.003	3	3
PDAC	LRRC66 →	+0.870	+0.170	.001	.008	3	2
CCRCC	TMEM156 →	-0.502	-0.168	<.001	.002	3	2
BRCA	SLC15A2 →	-0.599	-0.195	.002	.002	3	2
BRCA	RNU6V →	-0.760	-0.303	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,403 associations by consensus.

SERGEF vs USP47 — LSCC

Explore this scatter interactively →