SERGEF

Across TCGA patient cohorts, SERGEF mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERGEF-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and MEK1. Each is linked with SERGEF in more than 1 cancer types. Because this analysis shows association rather than direction, both SERGEF-to-partner and partner-to-SERGEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SERGEF-low versus SERGEF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERGEF→partner) and Y-score (partner→SERGEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.178	-3.459	<.001	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-1.986	.018	.032	3	1
UCEC	MEK1 →	+0.491	+2.000	.002	.032	3	1
UCEC	mTOR_pS2448 →	-0.209	-3.439	.001	.005	3	1
UCEC	Notch1 →	+0.297	+3.472	<.001	.002	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.526	-2.321	.009	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

A-Raf_pS299 by SERGEF expression — UCEC

Explore this box plot interactively →