SERGEF

Across TCGA cell cohorts, SERGEF RNA expression is significantly associated with the go_rna of many other GO terms, with 2,501 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SERGEF-associated GO terms across cancer lineages are Cellular detoxification of methylglyoxal, Response to methylglyoxal, and Methylglyoxal catabolic process. Each is linked with SERGEF in more than 9 cancer types. Because this analysis shows association rather than direction, both SERGEF-to-partner and partner-to-SERGEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular detoxification of methylglyoxal grouped by SERGEF-low versus SERGEF-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERGEF→partner) and Y-score (partner→SERGEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cellular detoxification of methylglyoxal →	+0.183	+0.829	<.001	<.001	3	10
OESOPHAGUS	Response to methylglyoxal →	+0.183	+0.829	<.001	<.001	3	10
OESOPHAGUS	Methylglyoxal catabolic process →	+0.179	+0.803	<.001	.001	3	10
OESOPHAGUS	Cellular response to methylglyoxal →	+0.183	+0.829	<.001	<.001	3	10
OESOPHAGUS	Methylglyoxal metabolic process →	+0.151	+1.093	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Cellular detoxification of aldehyde →	+0.156	+1.221	<.001	.009	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,501 associations by consensus.

Cellular detoxification of methylglyoxal by SERGEF expression — OESOPHAGUS

Explore this box plot interactively →