SERGEF

Across TCGA cell cohorts, SERGEF mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERGEF-associated genes across cancer lineages are ZNF831, MSGN1, and TBC1D21. Each is linked with SERGEF in more than 1 cancer types. Because this analysis shows association rather than direction, both SERGEF-to-partner and partner-to-SERGEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by SERGEF-low versus SERGEF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERGEF→partner) and Y-score (partner→SERGEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.014	+3.103	<.001	.004	3	1
LARGE_INTESTINE	MSGN1 →	+0.079	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CLEC14A →	+0.031	+4.378	<.001	<.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	LCN8 →	+0.140	+3.125	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ZNF831 by SERGEF expression — LARGE_INTESTINE

Explore this box plot interactively →