SERF2

Across TCGA cell cohorts, SERF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,915 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SERF2-associated GO terms across cancer lineages are Regulation of mitochondrial ATP synthesis coupled proton transport, Fatty acid catabolic process, and Monocarboxylic acid catabolic process. Each is linked with SERF2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SERF2-to-partner and partner-to-SERF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial ATP synthesis coupled proton transport grouped by SERF2-low versus SERF2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERF2→partner) and Y-score (partner→SERF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of mitochondrial ATP synthesis coupled proton transport →	+0.106	+0.673	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Fatty acid catabolic process →	+0.080	+0.860	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Monocarboxylic acid catabolic process →	+0.076	+0.951	<.001	<.001	3	8
CNS	Negative regulation of glial cell migration →	+0.235	+0.603	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Isocitrate metabolic process →	+0.143	+0.758	<.001	<.001	3	7
PANCREAS	Peptidyl-lysine hydroxylation →	+0.088	+0.397	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,915 associations by consensus.

Regulation of mitochondrial ATP synthesis coupled proton transport by SERF2 expression — BREAST

Explore this box plot interactively →