SERBP1

Across TCGA patient cohorts, SERBP1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERBP1-associated genes across cancer lineages are p70-S6K_pT389, FOXO3a, and Gab2. Each is linked with SERBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERBP1-to-partner and partner-to-SERBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by SERBP1-low versus SERBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERBP1→partner) and Y-score (partner→SERBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.222	-1.700	.005	.044	3	2
UCEC	FOXO3a →	-0.135	-2.085	.001	.018	3	1
UCEC	Gab2 →	+0.312	+1.700	.039	.044	3	1
UCEC	GATA6 →	-0.140	-2.985	.045	.034	3	1
UCEC	JNK2 →	+0.173	+1.700	.040	.044	3	1
UCEC	MEK1 →	+0.388	+2.700	.012	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

p70-S6K_pT389 by SERBP1 expression — UCEC

Explore this box plot interactively →