SERBP1

Across TCGA cell cohorts, SERBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,220 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SERBP1-associated GO terms across cancer lineages are DNA replication initiation, Ribosome biogenesis, and Mitotic spindle midzone assembly. Each is linked with SERBP1 in more than 18 cancer types. Because this analysis shows association rather than direction, both SERBP1-to-partner and partner-to-SERBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by SERBP1-low versus SERBP1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERBP1→partner) and Y-score (partner→SERBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.167	+1.089	<.001	<.001	3	19
BONE	Ribosome biogenesis →	+0.113	+0.782	<.001	.002	3	18
PANCREAS	Mitotic spindle midzone assembly →	+0.268	+1.178	<.001	<.001	3	18
BONE	rRNA processing →	+0.122	+0.872	<.001	<.001	3	18
PANCREAS	Mitotic spindle elongation →	+0.268	+1.178	<.001	<.001	3	18
BONE	Ribosomal large subunit biogenesis →	+0.133	+0.884	.006	.003	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,220 associations by consensus.

DNA replication initiation by SERBP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →