Across TCGA pan-cancer cohorts, SEPTIN9 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEPTIN9 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SEPTIN9 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPTIN9 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

OV, CCRCC, and LSCC are the cancer types where SEPTIN9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	All	0.516	0.922	.040	8	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	6	view →
LSCC	DFS	Quartile	III,IV	0.512	0.908	.033	3	view →
LUAD	OS	Median	All	0.997	0.928	.023	3	view →
PDAC	DFS	Quartile	III,IV	0.301	0.790	.048	3	view →
GBM	DFS	Tertile	All	0.173	0.357	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: SEPTIN9 tumor-vs-normal RNA expression · all SEPTIN9 data types