SEPTIN9

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SEPTIN9 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN9-associated genes across cancer lineages are PDCD4, Rad50, and Caveolin-1. Each is linked with SEPTIN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN9-to-partner and partner-to-SEPTIN9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN9→partner) and Y-score (partner→SEPTIN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADPDCD4 →-0.432-2.313.023.03532
COADRad50 →-0.386-3.169<.001.01732
COADCaveolin-1 →-0.830-3.169.009.01832
UCECMEK1 →+0.283+1.115.007.02632
UCECAkt_pT308 →+0.419+1.295.022.01032
UCECASNS →+0.312+2.087.002.00432
Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration