Across TCGA cell cohorts, SEPTIN9 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPTIN9-associated genes across cancer lineages are SH3GL2, OR10W1, and FAM205A. Each is linked with SEPTIN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN9-to-partner and partner-to-SEPTIN9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN9→partner) and Y-score (partner→SEPTIN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.742	+3.252	<.001	.009	2	2
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+3.029	<.001	.003	3	1
LUNG_NSCLC_LUAD	AMELX →	+0.076	+4.887	<.001	.009	3	1
BLOOD_Leukemia	BTBD16 →	+0.072	+2.696	<.001	.008	3	1
BLOOD_Leukemia	FLG2 →	+0.071	+2.685	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

SEPTIN9 survival (RNA) · tumor vs normal (RNA) · all SEPTIN9 data types