SEPTIN6

Across TCGA patient cohorts, SEPTIN6 mutation is significantly associated with the RNA expression of many other genes, with 2,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN6-associated genes across cancer lineages are RNA5SP158, MIR5186, and FBXO33. Each is linked with SEPTIN6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEPTIN6-to-partner and partner-to-SEPTIN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP158 grouped by SEPTIN6-low versus SEPTIN6-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN6→partner) and Y-score (partner→SEPTIN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP158 →	+0.324	+4.636	<.001	.006	3	3
THCA	MIR5186 →	+0.337	+7.962	<.001	.007	3	2
SKCM	FBXO33 →	+0.568	+3.478	.008	.002	3	2
SKCM	PTEN →	+0.868	+3.700	.001	.001	3	2
SKCM	ASB8 →	+0.556	+2.719	.001	.003	3	2
SKCM	TSN →	+0.580	+2.757	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,004 associations by consensus.

RNA5SP158 by SEPTIN6 expression — HNSC

Explore this box plot interactively →