SEPTIN6

Across TCGA patient cohorts, SEPTIN6 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN6-associated genes across cancer lineages are Rictor_pT1135, Src, and 4E-BP1. Each is linked with SEPTIN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN6-to-partner and partner-to-SEPTIN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by SEPTIN6-low versus SEPTIN6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN6→partner) and Y-score (partner→SEPTIN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.085	-1.643	.007	.003	3	2
UCEC	Src →	-0.146	-1.502	.022	.027	3	2
UCEC	4E-BP1 →	+0.333	+2.485	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.065	-2.088	.037	.016	3	1
UCEC	eIF4E →	+0.167	+2.415	.010	.003	3	1
UCEC	ERK2 →	+0.138	+1.415	.021	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Rictor_pT1135 by SEPTIN6 expression — UCEC

Explore this box plot interactively →