SEPTIN6

Across TCGA cell cohorts, SEPTIN6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,179 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPTIN6-associated GO terms across cancer lineages are U2-type prespliceosome assembly, DNA-templated transcription initiation, and Negative regulation of chromosome organization. Each is linked with SEPTIN6 in more than 12 cancer types. Because this analysis shows association rather than direction, both SEPTIN6-to-partner and partner-to-SEPTIN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, U2-type prespliceosome assembly grouped by SEPTIN6-low versus SEPTIN6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN6→partner) and Y-score (partner→SEPTIN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	U2-type prespliceosome assembly →	+0.120	+2.195	.007	.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.073	+1.454	.003	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.111	+1.550	.001	<.001	3	12
STOMACH	Microtubule polymerization →	+0.125	+1.558	<.001	.008	3	12
SOFT_TISSUE	mRNA transport →	+0.084	+1.262	.003	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Heterochromatin organization →	+0.078	+1.870	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,179 associations by consensus.

U2-type prespliceosome assembly by SEPTIN6 expression — BONE

Explore this box plot interactively →