Across TCGA patient cohorts, SEPTIN5 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN5-associated genes across cancer lineages are ERK2, FoxM1, and p62 Lck ligand. Each is linked with SEPTIN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN5-to-partner and partner-to-SEPTIN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN5→partner) and Y-score (partner→SEPTIN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.269	+3.459	<.001	.005	3	2
UCEC	FoxM1 →	+0.221	+1.906	.033	.016	3	2
UCEC	p62 Lck ligand →	+0.309	+2.415	.018	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.949	+2.720	<.001	.003	3	2
UCEC	4E-BP1 →	+0.257	+2.415	.018	.003	3	2
UCEC	Cyclin-E2 →	+0.165	+1.906	.015	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

SEPTIN5 survival (RNA) · tumor vs normal (RNA) · all SEPTIN5 data types