Across TCGA cell cohorts, SEPTIN5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SEPTIN5-associated genes across cancer lineages are CSN2, SPRR4, and OR2J1. Each is linked with SEPTIN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN5-to-partner and partner-to-SEPTIN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN5→partner) and Y-score (partner→SEPTIN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSN2 →	+0.031	+3.684	<.001	.006	3	1
LARGE_INTESTINE	SPRR4 →	+0.072	+3.930	.004	.003	3	1
LARGE_INTESTINE	OR2J1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ADAM7 →	+0.005	+3.930	<.001	.003	3	1
LUNG_NSCLC_LUAD	GPHB5 →	+0.039	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	FIGLA →	+0.030	+4.887	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

SEPTIN5 survival (RNA) · tumor vs normal (RNA) · all SEPTIN5 data types