SEPTIN3

Across TCGA pan-cancer cohorts, SEPTIN3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SEPTIN3 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SEPTIN3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SEPTIN3 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

GBM, CCRCC, and PDAC are the cancer types where SEPTIN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.872	0.656	.006	10	view →
CCRCC	DFS	Median	All	0.563	0.887	.012	8	view →
PDAC	DFS	Median	III,IV	1.000	0.584	.036	3	view →
LSCC	DFS	Median	All	0.622	0.909	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SEPTIN3–GBM (DFS)

Open the GBM breakdown →