Across TCGA pan-cancer cohorts, SEPTIN2P1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SEPTIN2P1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SEPTIN2P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEPTIN2P1 is over-expressed in tumor, although a few such as BLCA show the opposite, repressed pattern.

COAD, BLCA, and KIRP are the cancer types where SEPTIN2P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN2P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.779	<.001	7	view →
BLCA	All	III,IV	−0.249	.002	7	view →
KIRP	Female	All	+0.502	<.001	6	view →
READ	All	III,IV	+0.445	<.001	4	view →
BRCA	All	IV	+0.385	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SEPTIN2P1 RNA expression & survival · all SEPTIN2P1 data types