SEPTIN2

Across TCGA pan-cancer cohorts, SEPTIN2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEPTIN2 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEPTIN2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEPTIN2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

UCEC, GBM, and PDAC are the cancer types where SEPTIN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	III,IV	0.329	1.000	.024	12	view →
GBM	OS	Median	All	0.270	0.472	.004	10	view →
PDAC	OS	Quartile	III,IV	0.977	0.461	.016	7	view →
LSCC	OS	Median	All	0.715	1.000	.002	6	view →
HNSC	DFS	Tertile	II,III,IV	0.525	0.749	.016	4	view →
LUAD	DFS	Median	All	0.865	0.453	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEPTIN2–UCEC (OS)

Open the UCEC breakdown →