SEPTIN2

Across TCGA patient cohorts, SEPTIN2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN2-associated genes across cancer lineages are 14-3-3_beta, INPP4B, and MEK1. Each is linked with SEPTIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN2-to-partner and partner-to-SEPTIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SEPTIN2-low versus SEPTIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN2→partner) and Y-score (partner→SEPTIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.120	-3.143	.010	.018	3	1
UCEC	INPP4B →	-0.389	-2.459	.009	.018	3	1
UCEC	MEK1 →	+0.524	+3.700	.002	.001	3	1
UCEC	N-Ras →	-0.123	-2.571	.026	.011	3	1
UCEC	Shc_pY317 →	-0.177	-2.321	.012	.034	3	1
UCEC	Tuberin →	+0.362	+2.179	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by SEPTIN2 expression — UCEC

Explore this box plot interactively →