SEPTIN11

Across TCGA pan-cancer cohorts, SEPTIN11 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SEPTIN11 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEPTIN11 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEPTIN11 expression acts as an unfavorable survival marker, although some lineages such as GBM and COAD show a favorable association.

UCEC, LSCC, and GBM are the cancer types where SEPTIN11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	III,IV	0.346	1.000	.018	24	view →
LSCC	DFS	Median	II,III,IV	0.807	1.000	<.001	18	view →
GBM	OS	Quartile	All	0.795	0.348	<.001	11	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.408	.042	2	view →
HNSC	DFS	Median	IV	0.580	0.797	.013	2	view →
PDAC	DFS	Quartile	II,III,IV	0.868	0.549	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SEPTIN11–UCEC (OS)

Open the UCEC breakdown →