SEPTIN11

Across TCGA patient cohorts, SEPTIN11 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN11-associated genes across cancer lineages are PCNA, 14-3-3_beta, and EGFR_pY1068. Each is linked with SEPTIN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN11-to-partner and partner-to-SEPTIN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SEPTIN11-low versus SEPTIN11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN11→partner) and Y-score (partner→SEPTIN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.252	+2.459	.001	.018	3	2
UCEC	14-3-3_beta →	-0.090	-2.432	.012	.018	3	1
UCEC	EGFR_pY1068 →	-0.276	-1.925	.002	.005	3	1
UCEC	eIF4E →	+0.174	+3.472	.022	.002	3	1
UCEC	eIF4G →	+0.231	+1.874	.038	.049	3	1
UCEC	A-Raf_pS299 →	-0.119	-2.000	.005	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PCNA by SEPTIN11 expression — UCEC

Explore this box plot interactively →