Across TCGA pan-cancer cohorts, SEPTIN10 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SEPTIN10 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEPTIN10 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SEPTIN10 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, STAD, and LUSC are the cancer types where SEPTIN10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.928	0.303	.010	22	view →
STAD	OS	Median	All	0.184	0.730	.001	18	view →
LUSC	DFS	Median	All	1.000	0.653	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SEPTIN10 tumor-vs-normal RNA expression · all SEPTIN10 data types