Across TCGA pan-cancer cohorts, SEPTIN10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SEPTIN10 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SEPTIN10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPTIN10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PDAC, LUAD, and UCEC are the cancer types where SEPTIN10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.250	0.934	.024	7	view →
LUAD	DFS	Quartile	II,III,IV	0.245	0.675	.007	6	view →
UCEC	DFS	Median	All	0.972	0.838	.005	4	view →
HNSC	DFS	Median	IV	0.540	0.769	.023	3	view →
LSCC	OS	Median	II,III,IV	0.683	0.868	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SEPTIN10 tumor-vs-normal RNA expression · all SEPTIN10 data types